Chronic Toxicity Study of Neosaxitoxin in Rats
نویسندگان
چکیده
Neosaxitoxin (NeoSTX) is a specific reversible blocker of voltage gated sodium channels on excitable cells. In the last decade, it has been tested in a number of interesting clinical trials, however there is still little information available on mammalian toxicity. Rats were treated for 12 weeks with doses of 1, 3 or 6 μg/kg of subcutaneous NeoSTX. At weeks 12 and 17, animals were sacrificed and blood samples collected for hematological and biochemical analysis. Organs were harvested for weight determination and histopathological assessments. The lowest acute toxicity via the intraperitoneal (ip) route was (30.35 μg/kg) and there was no significant difference between intramuscular and subcutaneous routes (11.4 and 12.41 μg/kg). The NeoSTX adiministration did not produce lethality at week 12 and after five weeks of suspension. NeoSTX 6 μg/kg ip produced reductions (p < 0.05) in body weight and food intake, and increased blood level of total and direct bilirubin, GGT and SGOT at week 12; all of these were reversed in the recovery period. NeoSTX 1 and 3 μg/kg ip did not show significant changes with the control group. Histopathological presentations were normal in all groups. This study revealed that NeoSTX is safe in vivo, giving a reliable security margin for its use like a local anesthetic.
منابع مشابه
Acute and sub-chronic toxicological evaluation of ethanol extract of Solanum trilobatum Linn.
Background and objectives: Solanum trilobatum plant parts such as berries and flowers are normally used for the treatment of respiratory illnesses. The toxicity profile of the plant and its parts are not clear. Hence, the present study was planned to investigate the toxicological effects of ethanol extract of leaves of S. trilobatum (EEST) using acute and sub-...
متن کاملToxicity Evaluation of Essential oil of Trachyspermum ammi in Acute and Sub-chronic Toxicity Experiments
Background: Trachyspermum ammi is one of the prominent plant in traditional medicine of the east with several medicinal effects such as improvement of stomach disease, digestive disorder, diarrhea, hemorrhoid, bladder stones, respiratory disease and etc. Medicinal plants is one of the important reason of toxicity particularly in children and the elderly therefore, evaluation of the toxic effect...
متن کاملSub-Chronic Toxicity Study of Alpha-Cypermethrin in Rats
Alpha-cypermethrin (?-CP) a synthetic pyrethroid (type-II) insecticide, dissolved in dimethyl sulfoxide (DMSO-1ml) given consecutive daily orally for 60 days at 1/10LD50 (14.5mg/kg). The animals were sacrificed on day 61st. Biochemicals, cytochromeP450, b5 contents in liver along with antioxidant status, tissue residual concentration, and brain GABA level were studied. It increased the serum am...
متن کاملAcute toxicity of galega officinalis alcoholic extract in wistar rats
Galega officinalis (galega, Goat`s rue, French lilac) is a traditional plant from south east Europe. There are various reports about pharmacological properties of Galega officinalis such as diuretic, platelet aggregation, anti-bacterial, lactogen and anti-diabetic effect. There are a few studies about possible toxicological effect of this plant. In the present study, we evaluated the acute toxi...
متن کاملAcute toxicity of galega officinalis alcoholic extract in wistar rats
Galega officinalis (galega, Goat`s rue, French lilac) is a traditional plant from south east Europe. There are various reports about pharmacological properties of Galega officinalis such as diuretic, platelet aggregation, anti-bacterial, lactogen and anti-diabetic effect. There are a few studies about possible toxicological effect of this plant. In the present study, we evaluated the acute toxi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 12 شماره
صفحات -
تاریخ انتشار 2014